Memantine and dizocilpine interactions with antinociceptive or discriminative stimulus effects of morphine in rats after acute or chronic treatment with morphine
نویسندگان
چکیده
منابع مشابه
Evaluation of Antinociceptive Efficacy of pre versus post-incisional Morphine, Tramadol or Meloxicam in Rats
Objective- To evaluate antinociceptive efficacy of pre- versus post-incisional morphine, tramadol and meloxicam using tail-flick test in an incisional model of pain in rats. Design- Prospective, randomized experimental study. Animals- Eighty, adult, male Wistar rats weighing 250–300 g. Procedures- Animals were randomly divided into eight groups to receive pre- or post-incisional (tail skin i...
متن کاملRespiratory effects and amnesia after premedication with morphine or lorazepam.
Lorazepam, a new benzodiazepine, was compared with morphine for premedication. Ten patients received morphine 10 mg/70 kg i.m. and 10 received lorazepam 4 mg/70 kg i.m. Respiratory effects were assessed from the change in slope (S) and intercept (B) of the carbon dioxide response line, using a development of Read's rebreathing method. Morphine depressed S by 47% (P less than 0.01), but after lo...
متن کاملAntinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats
BACKGROUND Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. METHODS Male Sprague-Dawley rats weighing 220-240 g were used in all experiments. Rats subsequently receiv...
متن کاملThe synergistic antinociceptive interactions of morphine and dexmedetomidine in rats with nerve-ligation injury.
BACKGROUND Peripheral nerve injury may result in chronic neuropathic pain, which is characterized by spontaneous pain, hyperalgesia, and allodynia. Intrathecal administration of opioids and α2-adrenoceptor agonists produces spinal analgesia by activation of opioidergic and noradrenergic systems. In our study, we have compared the synergistic antiallodynic interaction and side-effects of intrath...
متن کاملAntagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys.
It has been suggested that heroin and morphine may act on different opioid receptor populations in rodents. In support of this hypothesis, the opioid antagonist 3-methoxynaltrexone was reported to be more potent as an antagonist of the antinociceptive effects of heroin than of morphine in mice and rats. To assess the generality of this finding across species and experimental endpoints, the pres...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2012
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-012-2807-9